Oxycodone in pregnancy should be used with caution, as it can affect both the mother and the developing baby. This opioid painkiller may cross the placenta, potentially causing withdrawal symptoms in newborns, low birth weight, premature delivery, or breathing difficulties after birth. Long-term or high-dose use increases these risks, especially in late pregnancy. While oxycodone may be prescribed for severe pain when the benefits outweigh the risks, it should only be used under close medical supervision. Expectant mothers are advised to avoid self-medicating and discuss safer pain management options with their healthcare provider to protect both maternal and fetal health.