Oxycodone and oxymorphone are strong opioid pain medications used for moderate to severe pain, but they differ in potency and formulation. Oxycodone is commonly prescribed in immediate- or extended-release forms and is slightly less potent than oxymorphone. Oxymorphone is stronger milligram-for-milligram and is typically reserved for patients who need higher-level pain control. Both carry risks of dependence, respiratory depression, constipation, nausea, and dizziness. Selection depends on pain severity, previous opioid response, and patient-specific factors. Both should be used under strict medical supervision to minimize overdose and addiction risks.