Percocet and Norco are prescription pain medications that combine an opioid with acetaminophen, but they differ in strength and formulation. Percocet contains oxycodone, a stronger opioid, making it more potent for moderate to severe pain. Norco contains hydrocodone, typically used for mild to moderate pain. Both come in various strengths and work by reducing pain signals in the brain, but Percocet generally provides stronger relief. Because both include acetaminophen, there is a risk of liver damage if taken in high doses. Side effects include drowsiness, nausea, and dependence. Both drugs require careful, supervised use to ensure safety.